报告题目：Oxidative Transformation of Alkenes Catalyzed by Bioinspired Osmium Complexes

报 告 人 ：Hideki Sugimoto教授

报告时间：2017年12月6日（周三）上午9:30

报告地点：化学楼二楼一号会议室

邀 请 人 ：尹国川教授

报告人简介：

Prof. Sugimoto received his PhD from Hokkaido University with Prof. Yoichi Sasaki in 1997. After that, he joined Osaka City University as an assistant professor; in 2009, he moved to Osaka University as an associate professor. His current research focuses on modeling of non-heme enzyme active sites, including model synthesis, reaction mechanism, catalytic reaction, metal-chalcogen multiple bond. Up to now, he has published more than 170 papers including JACS (12) and CSR (1).

Metalloenzyme active sites often tell us how to design molecules that work as efficient and atom economical catalysts. Rieske dioxygenase is an iron containing enzyme that catalyzes cis-1,2- dihydroxylation of arenes with O₂ or H₂O₂.  A mononuclear oxido-hydroxido-iron(V), (Fe^V(O)(OH)), center has been proposed as an active oxidant for the reaction.  However, the active oxidant structure of the enzyme has not been modeled yet. In this presentation, he will present his recent studies on osmium substituted model complex of Rieske dioxygenase coordinated with a tetradentate ligand, TPA, and its catalytic activity in cis-dihydroxylation of alkenes with H₂O₂ and chramine-T oxidant.